Molecule Information

General Information of the Molecule (ID: Mol00841)

Name	Beta-lactamase (BLA) ,Mycolicibacterium fortuitum
Synonyms	Penicillinase Click to Show/Hide
Molecule Type	Protein
Gene Name	blaF
Sequence	MTGLSRRNVLIGSLVAAAAVGAGVGGAAPAFAAPIDDQLAELERRDNVLIGLYAANLQSG RRITHRLDEMFAMCSTFKGYAAARVLQMAEHGEISLDNRVFVDADALVPNSPVTEARAGA EMTLAELCQAALQRSDNTAANLLLKTIGGPAAVTAFARSVGDERTRLDRWEVELNSAIPG DPRDTSTAAALAVGYRAILAGDALSPPQRGLLEDWMRANQTSSMRAGLPEGWTTADKTGS GDYGSTNDAGIAFGPDGQRLLLVMMTRSQAHDPKAENLRPLIGELTALVLPSLL Click to Show/Hide
Uniprot ID	BLAF_MYCFO
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Corynebacteriales Family: Mycobacteriaceae Genus: Mycolicibacterium Species: Mycolicibacterium fortuitum

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

Click to Show/Hide the Full List of Drugs

Amoxicillin

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Mycobacterium fortuitum infection			[1]
Resistant Disease	Mycobacterium fortuitum infection [ICD-11: 1B2Z.2]		Disease Info
Resistant Drug	Amoxicillin		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli strain HB101		634468
	Escherichia coli strain MC1061		1211845
	Escherichia coli strain XL1-Blu9		562
	Mycolicibacterium fortuitum strain D316		1766
	Mycolicibacterium fortuitum strain FC1		1766
	Mycolicibacterium smegmatis strain mc^155		246196
Experiment for Molecule Alteration	SDS-polyacrylamide gel assay
Experiment for Drug Resistance	MIC assay
Mechanism Description	The gene encoding a class A (t-lactamase was cloned from a natural Isolate of Mycobacterium fortuitum {blaF) and from a high-level amoxicillJn-resistant mutant that produces large amounts of p-lactamase (blaF*).

References

Ref 1	Transcription and expression analysis, using lacZ and phoA gene fusions, of Mycobacterium fortuitum beta-lactamase genes cloned from a natural isolate and a high-level beta-lactamase producer. Mol Microbiol. 1994 May;12(3):491-504. doi: 10.1111/j.1365-2958.1994.tb01037.x.