Molecule Information

General Information of the Molecule (ID: Mol00827)

Name	Beta-lactamase (BLA) ,Pseudomonas aeruginosa
Synonyms	blaOxa-50c; blaOXA-50b; blaOXA-50g; IPC1494_23315; IPC152_19190; IPC1595_21065; IPC57_19425; IPC607_22635; EC 3.5.2.6; OXA-50 family oxacillin-hydrolyzing class D beta-lactamase OXA-488; Oxacillinase Click to Show/Hide
Molecule Type	Protein
Gene Name	blaOxa-50c
Sequence	MRPLLFSALLLLSGHAQASEWNDSRAVDKLFGAAGVKGTFVLYDVQRQRYVGHDRERAET RFVPASTYKVANSLIGLSTGAVRSADEVLPYGGKPQRFKAWEHDMSLRDAIKASNVPVYQ ELARRIGLERMRANVSRLGYGNAEIGQVVDNFWLVGPLKISAMEQTRFLLRLAQGELPFP APVQSTVRAMTLLESGPGWELHGKTGWCFDCTPELGWWVGWVKRNERLYGFALNIDMPGG EADIGKRVELGKASLKALGILP Click to Show/Hide
Uniprot ID	Q6JTT6_PSEAI
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Pseudomonadaceae Genus: Pseudomonas Species: Pseudomonas aeruginosa

Type(s) of Resistant Mechanism of This Molecule

DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Ampicillin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Drug Inactivation by Structure Modification (DISM)		Click to Show/Hide
Disease Class: Pseudomonas aeruginosa infection			[1]
Resistant Disease	Pseudomonas aeruginosa infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Ampicillin		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Pseudomonas aeruginosa PAO1		208964
Experiment for Molecule Alteration	DNA sequencing and protein assay
Experiment for Drug Resistance	Disk diffusion assay
Mechanism Description	P. aeruginosa harbors two naturally encoded Beta-lactamase genes, one of which encodes an inducible cephalosporinase and the other of which encodes a constitutively expressed oxacillinase. OXA-50 is a kind of oxacillinase which lead to drug resistance.

References

Ref 1	Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2004 Jun;48(6):2043-8. doi: 10.1128/AAC.48.6.2043-2048.2004.