Molecule Information

General Information of the Molecule (ID: Mol00826)

• Name: Beta-lactamase (BLA) ,Escherichia coli
• Synonyms: bla; bla TEM-1; bla_1; bla_2; blaTEM; BlaTEM-1; blaTEM-1; blaTEM-116; blaTEM-1B; blaTEM-1b; blaTEM-1D; blaTEM1; blaTEM1D; blaTEM1E; blaTEM1F; A2F99_004554; A2F99_004666; A9X72_26835; AWP47_17940; AWP93_00390; B6R12_004739; B6R12_005526; B6R15_005206; B6R15_005523; BANRA_04773; BANRA_05427; BFL24_24620; BG944_002911; BG944_005713; BHS81_30510; BIZ41_10685; BJI68_26345; BO068_005319; BO068_005477; BON66_02690; BON67_03845; BON68_19145; BON69_00465; BON70_01975; BON71_00055; BON72_28760; BON75_23670; BON76_21975; BON81_25130; BON82_05385; BON83_24205; BON86_07485; BON88_06945; BON89_06025; BON94_02815; BON96_02690; BON97_18680; BON98_03600; BSR05_26525; BVL39_07935; BVL39_07960; BXT93_06865; C2121_004654; C2121_005384; CCS08_09025; CDL36_20780; CG831_004349; CG831_004504; CO706_01105; CO706_17370; CQP61_30495; CWS33_22125; CX692_004596; CX692_004719; CX693_004596; CX693_004721; CX699_004527; CX699_004672; CXJ73_005347; CXJ73_006204; CY655_27570; D3822_31045; D3C88_10830; D3G36_26695; D3G36_27505; D4U49_22295; D4U49_28905; D9C02_24990; D9D77_20430; D9D77_28935; D9J61_26735; D9J61_26740; D9J61_26745; D9J61_26750; D9J61_26755; D9J61_26760; DAH37_27405; DAH50_26125; DKP82_25825; DNX30_29295; DNX30_30505; DU321_26460; DXT70_23345; E2114_26540; E2115_26450; E2116_26650; E2118_26645; E2120_26945; E2122_14285; E2123_26540; E2124_26660; E2125_26620; E2128_25025; E2130_26595; E2131_25090; E2135_22030; E2136_26925; E5P22_20565; E5P23_12820; E5P23_13380; E5P24_23910; E5P25_24710; E5P30_23990; E5P37_17910; E5P51_01875; E5P52_21745; E5S34_22695; E5S35_22580; E5S39_22165; E5S43_22320; EA435_26350; EHH55_26375; EI021_25945; EIZ93_28475; EKI52_29585; ELT20_23760; ELT22_24990; ELT25_25950; ELT26_23465; ELT31_25650; ELT31_26030; ELT32_25300; ELT36_25095; ELT36_25560; ELT39_25205; ELT40_25345; ELT48_24185; ELT48_26800; ELT49_23665; ELT55_26225; ELT56_21465; ELU91_25690; ELU97_22830; ELV10_25830; ELV12_25815; ELV20_25130; ELV21_27315; ELV23_25740; ELV24_24545; ELV24_25955; ELV28_24995; ELV28_29525; ELV29_22900; ELX56_24795; ELX56_26000; ELX68_15695; ELX68_26135; ELY05_22530; ELY05_24915; EPS76_27635; ERS085406_05171; ETECE562_05056; ETN48_p0069; EVY14_27485; EXX13_05385; EYV18_22010; F9B07_25495; FDM60_13440; FDM60_28130; FE587_19010; FE587_27705; FEJ01_26155; FEJ01_27540; FGG80_21220; FJQ51_26745; FJQ51_27795; FTV92_27545; FTV93_29765; FWK02_02110; FY127_09010; FZN31_00540; G4A38_27760; G9448_23805; G9448_25615; GF147_26500; GF147_27220; GFY34_25275; GFY34_26415; GKE84_18035; GLW94_27210; GLW94_28255; GP650_26385; GP979_22355; GQE64_24875; GQW07_26790; GQW68_26185; GQW68_27145; GQW80_26180; GQW80_27605; GRO95_26845; GRW05_13885; GRW57_26480; GRW77_24710; GTP88_26265; GTP88_26850; HHH44_005310; HHH44_005312; HJS37_003877; HJS37_005198; HKA49_005153; HKA49_005608; HLZ50_24695; HLZ50_26680; HMJ82_29245; HMJ82_29250; HMJ82_29255; HMJ82_29260; HMU06_23660; HMU06_28740; HMV95_25095; HMV95_26455; HNC36_28295; HNC36_29435; HNC59_27740; HNC59_29670; HNC66_22940; HNC66_27545; HNC99_29675; HND12_30830; HVX16_26760; HX136_25470; HX136_25960; IH768_20880; IPF_160; IT029_005376; IT029_005543; JE86ST02C_05370; JE86ST05C_05430; JNP96_28840; JNP96_30605; NCTC12950_01033; NDM1Dok01_N0178; O2R_124; pEC012_00011; pEC012_00036; pG5A4Y217_19; pHN3A11_016; pHN7A8_020; pHNFP460_046; pOLA52_03; R6K_0002; RCS30_P0189; RCS35_PII0008; RCS37_PI0008; RCS39_P0009; RCS49_PIII0009; RCS55_PI0069; RCS57_p0075; RCS57TR364_P0005; RCS59_P0142; RCS65_P0143; rpec180_8; SAMEA3472056_05622; SAMEA3472080_04547; SAMEA3751407_05223; SAMEA3752557_04872; SAMEA4363221_00075; SAMEA4370473_00028; TUM18780_19120; TUM18780_46010
• Molecule Type: Protein
• Gene Name: TEM-1
• Gene ID: 67514328
• Sequence:
  MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRP
  EERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVREL
  CSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTM
  PAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGS
  RGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
• Uniprot ID: Q6SJ61_ECOLX

Kingdom: N.A.
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Ampicillin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Escherichia coli infection [1]

• Resistant Disease: Escherichia coli infection [ICD-11: 1A03.0]
• Resistant Drug: Ampicillin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Escherichia coli Co227; 562
• In Vitro Model: Escherichia coli Co228; 562
• In Vitro Model: Escherichia coli Co356; 562
• Experiment for Molecule Alteration: PCR; PCR-restriction fragment length polymorphism analysis; Sequencing assay
• Experiment for Drug Resistance: Agar dilution method assay
• Mechanism Description: Multiple-antibiotic-resistant phenotype is associated with gene mutation and mar locus regulation.

References

• Ref 1: Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins. Antimicrob Agents Chemother. 2004 Oct;48(10):3996-4001. doi: 10.1128/AAC.48.10.3996-4001.2004.