Molecule Information

General Information of the Molecule (ID: Mol00809)

Name	ATP-binding protein (ABP) ,Streptomyces antibioticus
Synonyms	oleB; ATP-binding protein Click to Show/Hide
Molecule Type	Protein
Gene Name	oleB
Sequence	MQNAHRSDTGAAALTGTPEKLLPTQPETGSFQVVLDDVVRAPGGRPLLDGVNQSVALGER VGIIGENGSGKSTLLRMLAGVDRPDGGQVLVRAPGGCGYLPQTPDLPPEDTVQDAIDHAL AELRSLERGLREAEQALAGAEPEELEGLLGAYGDLLEAFEARDGYAADARVDAAMHGLGL AGITGDRRLGSLSGGEQARLNLACLLAASPQLMLLDEPTNHLDVGALEWLEERLRAHRGS VLVVSHDRVFLERVATALWEVDGERRTVNRHGGGYAGYLQAKAAARRRWEQAYQDWLEDL ARQRELARSAADHLATGPRRNTERSNQRHQRNVEKQISARVRNAKERVRRLEENPVPRPP QPMRFRARVEGGGTVGRGGALAELYKVTVGTRLDVPSFTVDPGERILITGHNGAGKSTLL RVLAGDLAPDQGECERPERIGWLPQETEITDRQQSLLAAFAAGLPGIAEEHRGALLGFGL FRPSALGTAVGDLSTGQLRRLALARLLRDPADLLLLDEPTNHLSPALVEDLEEALAHYRG ALVVVSHDRMFAQRFTGRRMHMEGGRFVE Click to Show/Hide
Uniprot ID	Q53712_STRAT
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Actinobacteria Class: Actinomycetia Order: Streptomycetales Family: Streptomycetaceae Genus: Streptomyces Species: Streptomyces antibioticus

Type(s) of Resistant Mechanism of This Molecule

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Matromycin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Disease Class: Streptomyces antibioticus infection			[1]
Resistant Disease	Streptomyces antibioticus infection [ICD-11: 1C43.1]		Disease Info
Resistant Drug	Matromycin		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Streptomyces antibioticus strain		1890
Experiment for Molecule Alteration	Fluorescence measurements assay
Mechanism Description	The OleB protein ofStreptomyces antibioticus, oleandomycin (OM) producer, constitutes an ATP-binding cassette transporter containing two nucleotide-binding domains and is involved in OM resistance and its secretion in this producer strain.

References

Ref 1	Interaction between ATP, oleandomycin and the OleB ATP-binding cassette transporter of Streptomyces antibioticus involved in oleandomycin secretion. Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):139-44. doi: 10.1042/bj3210139.