Molecule Information

General Information of the Molecule (ID: Mol00770)

• Name: Aminocyclitol acetyltransferase ApmA (APMA) ,Staphylococcus aureus
• Synonyms: apmA; Aminocyclitol acetyltransferase ApmA
• Molecule Type: Protein
• Gene Name: apmA
• Sequence:
  MKTRLEQVLERYLNGREVAVWGVPTRRLLRALKPFKFHTADRVDPQYHYVVAVTDDDLTD
  FLSDEQSKSFQYANDYLTFDDEGGELPFERMCFNVPVGRQTYFGDGVVGACENGYIKSIG
  QFTSINGTAEIHANHQLNMTFVSDDIQNFFNEESMAVFQEKLRKDPKHPYAYSKEPMTIG
  SDVYIGAHAFINASTVTSIGDGAIIGSGAVVLENVPPFAVVVGVPARIKRYRFSKEMIET
  LLRVKWWDWSIEEINENVDALISPELFMKKYGSL
• Uniprot ID: A0A1D0AST6_STAAU

Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Staphylococcus
Species: Staphylococcus aureus

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Clinical Trial Drug(s) 1 drug(s) in total

Apramycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Bacterial infection [1]

• Resistant Disease: Bacterial infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Apramycin
• Molecule Alteration: Expression; Up-regulation
• Experimental Note: Discovered Using In-vivo Testing Model
• In Vitro Model: Staphylococcus aureus RN4220; 1280
• In Vitro Model: Escherichia coli JM101; 562
• In Vitro Model: Staphylococcus aureus ST398; 523796
• Experiment for Molecule Alteration: Whole genome sequence assay; Allelic frequency measurement assay
• Experiment for Drug Resistance: Broth microdilution method assay
• Mechanism Description: The apmA gene coded for a protein of 274 amino acids that was related only distantly to acetyltransferases involved in chloramphenicol or streptogramin A resistance.

References

• Ref 1: Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. Antimicrob Agents Chemother. 2011 Jan;55(1):373-5. doi: 10.1128/AAC.01124-10. Epub 2010 Sep 27.