Molecule Information

General Information of the Molecule (ID: Mol00769)

Name	Alternative penicillin-binding protein 2a (MECD) ,Macrococcus caseolyticus
Synonyms	mecD; mec; CW686_07055; PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecD Click to Show/Hide
Molecule Type	Protein
Gene Name	mecD
Sequence	MKNIKVKILIVCSLCLISFFLYNLLKENEIDKIFSSIENRNVDEINENITFLSRNTFSKK QRYDRMNHIDNSLGIKKVNITDIKLLEEIVDTRKYSANMHYDSKFGKFTKKGYFEFEKNG ESKRWELNWTPEVIIPGLTATNEVRVEELKSSRGEIVDRNGIPLAIDGEHYQVGIDPKNY NKKDSKQIAKLLNINESTLKNKLKQSWVKDGVFVPIKSYVELSDEIKNKIPEYGLSVNKI KGRTYPLKEASAHLLGYIGEINADELNDPKFKGYDSHSIVGKTGIEYMYDKELQNRDGLI VYITDDDGLTDSKEILVHKKPKNGKKIVLSIDSRVQNSIYNHLKDDNGSGTAMNPKTGEL LALVSYPSFNPYDFMFGISNKKYQALLNDKKAPLLNKFQELTSPGSTQKLLTSIIGLNNG VINESKSYEINGKGWRKDGSWGGYKVTRFEVVNGRIDLEKAIAHSDNIFFARTTLEMGGK KFVRGMKDLGVGEETPSDYPVRTGQIANKINLERNLNNDILLADSGYGQGEILVNPIHIL SIYSSLVNEGNMMAPKLNMEHKSKVWKKHITSQKNIDILTSSMRKVVTGTHKLDTERNYA NFAGKTGTAELKMTQNEGLGTQIGWFVGYDQQNPNMMLAINVKNVEDKGMSSYNAQKFAQ VMDDLYEHGARTYEPDSE Click to Show/Hide
Uniprot ID	A0A1S7BGS4_9STAP
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Firmicutes Class: Bacilli Order: Bacillales Family: Staphylococcaceae Genus: Macrococcus Species: Macrococcus caseolyticus

Type(s) of Resistant Mechanism of This Molecule

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Meticillin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)		Click to Show/Hide
Disease Class: Bacterial infection			[1]
Resistant Disease	Bacterial infection [ICD-11: 1A00-1C4Z]		Disease Info
Resistant Drug	Meticillin		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Macrococcus caseolyticus strains		69966
Experiment for Molecule Alteration	PCR; DNA sequence assay
Mechanism Description	Methicillin-resistant Macrococcus caseolyticus strains from bovine and canine origins were found to carry a novel mecD gene conferring resistance to all classes of Beta-lactams including anti-MRSA cephalosporins. Association of Beta-lactam resistance with mecD was demonstrated by gene expression in S. aureus and deletion of the mecD-containing island in M. caseolyticus.

References

Ref 1	Novel methicillin resistance gene mecD in clinical Macrococcus caseolyticus strains from bovine and canine sources. Sci Rep. 2017 Mar 8;7:43797. doi: 10.1038/srep43797.