Molecule Information

General Information of the Molecule (ID: Mol00759)

• Name: AADA9 protein (AADA9) ,Corynebacterium glutamicum
• Synonyms: aadA9; AADA9 protein
• Molecule Type: Protein
• Gene Name: aadA9
• Sequence:
  MSNSIHTGISRQLSQARDVIKRHLASTLKAIHLYGSAIDGGLKPYSDIDLLVTVDARLDE
  ATRRSLMLDFLNISAPPCESSILRPLEVTVVACNEVVPWRYPARRELQFGEWLREDILEG
  VFEPAALDADLAILITKARQHSIALVGPVAQKVFMPVPEHDFLQVLSDTLKLWNTHEDWE
  NEERNIVLTLARIWYSTETGGIVPKDVAAEWVLERLPAEHKPILVEARQAYLGLCKDSLA
  LRADETSAFIGYAKSAVADLLEKRKSQTSHICDGAKNV
• Uniprot ID: Q8VVI9_CORGT

Kingdom: N.A.
Phylum: Actinobacteria
Class: Actinomycetia
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium glutamicum

Type(s) of Resistant Mechanism of This Molecule

  DISM: Drug Inactivation by Structure Modification

Drug Resistance Data Categorized by Drug

Approved Drug(s) 2 drug(s) in total

Spectinomycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Corynebacterium glutamicum infection [1]

• Resistant Disease: Corynebacterium glutamicum infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Spectinomycin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Corynebacterium glutamicum ATCC 13032; 196627
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Macrodilution broth method assay
• Mechanism Description: AadA9 is a novel aminoglycoside adenyltransferase gene cassette which lead to drug resistance.

Streptomycin

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Drug Inactivation by Structure Modification (DISM)

Disease Class: Corynebacterium glutamicum infection [1]

• Resistant Disease: Corynebacterium glutamicum infection [ICD-11: 1A00-1C4Z]
• Resistant Drug: Streptomycin
• Molecule Alteration: Expression; Inherence
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Corynebacterium glutamicum ATCC 13032; 196627
• Experiment for Molecule Alteration: DNA sequencing assay
• Experiment for Drug Resistance: Macrodilution broth method assay
• Mechanism Description: AadA9 is a novel aminoglycoside adenyltransferase gene cassette which lead to drug resistance.

References

• Ref 1: The 27.8-kb R-plasmid pTET3 from Corynebacterium glutamicum encodes the aminoglycoside adenyltransferase gene cassette aadA9 and the regulated tetracycline efflux system Tet 33 flanked by active copies of the widespread insertion sequence IS6100. Plasmid. 2002 Sep;48(2):117-29. doi: 10.1016/s0147-619x(02)00120-8.