Molecule Information
General Information of the Molecule (ID: Mol00738)
Name |
Tiamulin efflux ATP-binding protein (TAEA)
,Paenibacillus sp.
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Synonyms |
taeA; AK95_19955; Tiamulin efflux ATP-binding protein
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Molecule Type |
Protein
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Gene Name |
taeA
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Sequence |
MNILTVEQVTKSYGDKILFQDASFGMEDQDKIGIIGVNGTGKSTFLRVIAGLEPPDSGKI
SMGNRIRVRYLAQNPEFDPDKTVLQQVFEGDLPEMKAVREYTETMELLELHPSHEELQQK LLKLNQTLETLQAWQLESDAKTILSKLGIRNYEAKMGTLSGGQRKRVALAAALIQPSDLL ILDEPTNHIDNESVAWLEQYLQKRRGALLMITHDRYFLDRVANVMLELDHGRLFRYEANY SRFLELKAEREEREAASEQKRQNLLRSELAWIRRGAKARTTKQKARIERFEKLKDQEMVH SSGELDVSVASTRLGRKILEIEGLRMKIDDKTLIQDLSYIAVPEDRIGIVGPNGSGKSTL LNLIAGRIQPGGGEVVLGPTVKLGYFTQEHQEMDGSQRVIEYIKDEAEVVRTADGSAITA AQMLERFLFPPALQWTPIAKLSGGEKRRLYLLRVLMSAPNVLLLDEPTNDLDIQTLSVLE QYLDEFPGVCIVVSHDRFFLDRTVDKIMAFEGDGQIRVHVGSYSEYAEWMQRHGGEASGS KAEASIAKSASGSSDGTDSDSAKEAPRERLKFSYKEQREFDQIDGLIEDTESKLASIQSE METAGSDAARLQELMKAQEETERELEHLMERWTYLNELAEKIEQSKKS Click to Show/Hide
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Uniprot ID | |||||
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Type(s) of Resistant Mechanism of This Molecule
IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
Pleuromutilins
Drug Resistance Data Categorized by Their Corresponding Mechanisms | ||||
Irregularity in Drug Uptake and Drug Efflux (IDUE) | ||||
Disease Class: Bacterial infection | [1] | |||
Resistant Disease | Bacterial infection [ICD-11: 1A00-1C4Z] | |||
Resistant Drug | Pleuromutilins | |||
Molecule Alteration | Expression | Inherence |
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Experimental Note | Discovered Using In-vivo Testing Model | |||
In Vitro Model | Paenibacillus sp. LC231 | 1120679 | ||
Experiment for Molecule Alteration |
Whole genome sequence assay | |||
Mechanism Description | These new resistance elements are discussed below. We also identified two predicted ABC-transporters that confer resistance to tetracycline (TetAB(48)) and tiamulin (TaeA). |
References
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