General Information of the Molecule (ID: Mol00738)
Name
Tiamulin efflux ATP-binding protein (TAEA) ,Paenibacillus sp.
Synonyms
taeA; AK95_19955; Tiamulin efflux ATP-binding protein
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Molecule Type
Protein
Gene Name
taeA
Sequence
MNILTVEQVTKSYGDKILFQDASFGMEDQDKIGIIGVNGTGKSTFLRVIAGLEPPDSGKI
SMGNRIRVRYLAQNPEFDPDKTVLQQVFEGDLPEMKAVREYTETMELLELHPSHEELQQK
LLKLNQTLETLQAWQLESDAKTILSKLGIRNYEAKMGTLSGGQRKRVALAAALIQPSDLL
ILDEPTNHIDNESVAWLEQYLQKRRGALLMITHDRYFLDRVANVMLELDHGRLFRYEANY
SRFLELKAEREEREAASEQKRQNLLRSELAWIRRGAKARTTKQKARIERFEKLKDQEMVH
SSGELDVSVASTRLGRKILEIEGLRMKIDDKTLIQDLSYIAVPEDRIGIVGPNGSGKSTL
LNLIAGRIQPGGGEVVLGPTVKLGYFTQEHQEMDGSQRVIEYIKDEAEVVRTADGSAITA
AQMLERFLFPPALQWTPIAKLSGGEKRRLYLLRVLMSAPNVLLLDEPTNDLDIQTLSVLE
QYLDEFPGVCIVVSHDRFFLDRTVDKIMAFEGDGQIRVHVGSYSEYAEWMQRHGGEASGS
KAEASIAKSASGSSDGTDSDSAKEAPRERLKFSYKEQREFDQIDGLIEDTESKLASIQSE
METAGSDAARLQELMKAQEETERELEHLMERWTYLNELAEKIEQSKKS
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Uniprot ID
A0A1I9ZKK9_9BACL
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Kingdom: N.A.
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Paenibacillaceae
Genus: Paenibacillus
Species: Paenibacillus sp.
Type(s) of Resistant Mechanism of This Molecule
  IDUE: Irregularity in Drug Uptake and Drug Efflux
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Pleuromutilins
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Irregularity in Drug Uptake and Drug Efflux (IDUE) Click to Show/Hide
Disease Class: Bacterial infection [1]
Resistant Disease Bacterial infection [ICD-11: 1A00-1C4Z]
Resistant Drug Pleuromutilins
Molecule Alteration Expression
Inherence
Experimental Note Discovered Using In-vivo Testing Model
In Vitro Model Paenibacillus sp. LC231 1120679
Experiment for
Molecule Alteration
Whole genome sequence assay
Mechanism Description These new resistance elements are discussed below. We also identified two predicted ABC-transporters that confer resistance to tetracycline (TetAB(48)) and tiamulin (TaeA).
References
Ref 1 A diverse intrinsic antibiotic resistome from a cave bacterium. Nat Commun. 2016 Dec 8;7:13803. doi: 10.1038/ncomms13803.

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