Molecule Information

General Information of the Molecule (ID: Mol00723)

Name	Dihydropteroate synthase (SUL) ,Escherichia coli
Synonyms	Dihydropteroate pyrophosphorylase type I; Dihydropteroate synthase type I; DHPS; sul1 Click to Show/Hide
Molecule Type	Protein
Gene Name	sul1/sul2/ sul3
Gene ID	67375551
Function	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives (By similarity). It is implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly. Click to Show/Hide
Uniprot ID	DHP1_ECOLX/Q6UUU7_ECOLX /Q6RSI4_ECOLX
*Click to Show/Hide the Complete Species Lineage*
Kingdom: N.A. Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Escherichia Species: Escherichia coli

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Nalidixic acid

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)		Click to Show/Hide
Disease Class: Escherichia coli infection			[1]
Resistant Disease	Escherichia coli infection [ICD-11: 1A03.0]		Disease Info
Resistant Drug	Nalidixic acid		Drug Info
Molecule Alteration	Expression	Inherence
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli Co227		562
	Escherichia coli Co228		562
	Escherichia coli Co232		562
	Escherichia coli Co354		562
Experiment for Molecule Alteration	PCR; PCR-restriction fragment length polymorphism analysis; Sequencing assay
Experiment for Drug Resistance	Agar dilution method assay
Mechanism Description	Multiple-antibiotic-resistant phenotype is associated with gene mutation and mar locus regulation.

References

Ref 1	Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins. Antimicrob Agents Chemother. 2004 Oct;48(10):3996-4001. doi: 10.1128/AAC.48.10.3996-4001.2004.