Molecule Information

General Information of the Molecule (ID: Mol00566)

Name	Lysophosphatidic acid acyltransferase beta (AGPAT2) ,Homo sapiens
Synonyms	1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; Lysophosphatidic acid acyltransferase beta; LPAAT-beta Click to Show/Hide
Molecule Type	Protein
Gene Name	AGPAT2
Gene ID	10555
Location	chr9:136673143-136687457[-]
Sequence	MELWPCLAAALLLLLLLVQLSRAAEFYAKVALYCALCFTVSAVASLVCLLRHGGRTVENM SIIGWFVRSFKYFYGLRFEVRDPRRLQEARPCVIVSNHQSILDMMGLMEVLPERCVQIAK RELLFLGPVGLIMYLGGVFFINRQRSSTAMTVMADLGERMVRENLKVWIYPEGTRNDNGD LLPFKKGAFYLAVQAQVPIVPVVYSSFSSFYNTKKKFFTSGTVTVQVLEAIPTSGLTAAD VPALVDTCHRAMRTTFLHISKTPQENGATAGSGVQPAQ Click to Show/Hide
Function	Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Click to Show/Hide
Uniprot ID	PLCB_HUMAN
Ensembl ID	ENSG00000169692
HGNC ID	HGNC:325
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Cisplatin

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Osteosarcoma				[1]
Sensitive Disease	Osteosarcoma [ICD-11: 2B51.0]			Disease Info
Sensitive Drug	Cisplatin			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	MG63 cells	Bone marrow	Homo sapiens (Human)	CVCL_0426
	SAOS-2 cells	Bone marrow	Homo sapiens (Human)	CVCL_0548
	MG63/CDDP cells	Bone	Homo sapiens (Human)	CVCL_0426
	SAOS-2/CDDP cells	Bone	Homo sapiens (Human)	CVCL_0548
Experiment for Molecule Alteration	Western blot analysis
Experiment for Drug Resistance	CCK8 assay; Annexin V-FITC apoptosis assay
Mechanism Description	microRNA-340-5p modulates cisplatin resistance by targeting LPAATbeta in osteosarcoma.

References

Ref 1	MicroRNA-340-5p modulates cisplatin resistance by targeting LPAATBeta in osteosarcoma. Braz J Med Biol Res. 2017 Apr 20;50(5):e6359. doi: 10.1590/1414-431X20176359.