Molecule Information

General Information of the Molecule (ID: Mol00417)

Name	Homeobox protein Hox-A3 (HOXA3) ,Homo sapiens
Synonyms	Homeobox protein Hox-1E; HOX1E Click to Show/Hide
Molecule Type	Protein
Gene Name	HOXA3
Gene ID	3200
Location	chr7:27106184-27152583[-]
Sequence	MQKATYYDSSAIYGGYPYQAANGFAYNANQQPYPASAALGADGEYHRPACSLQSPSSAGG HPKAHELSEACLRTLSAPPSQPPSLGEPPLHPPPPQAAPPAPQPPQPAPQPPAPTPAAPP PPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSSSSSGESCA GDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQ NRRMKYKKDQKGKGMLTSSGGQSPSRSPVPPGAGGYLNSMHSLVNSVPYEPQSPPPFSKP PQGTYGLPPASYPASLPSCAPPPPPQKRYTAAGAGAGGTPDYDPHAHGLQGNGSYGTPHI QGSPVFVGGSYVEPMSNSGPALFGLTHLPHAASGAMDYGGAGPLGSGHHHGPGPGEPHPT YTDLTGHHPSQGRIQEAPKLTHL Click to Show/Hide
Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Click to Show/Hide
Uniprot ID	HXA3_HUMAN
Ensembl ID	ENSG00000105997
HGNC ID	HGNC:5104
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

2 drug(s) in total

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Dexamethasone

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Acute lymphocytic leukemia				[1]
Resistant Disease	Acute lymphocytic leukemia [ICD-11: 2B33.0]			Disease Info
Resistant Drug	Dexamethasone			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	EGFR/RAS/RAF/MEK/ERK signaling pathway		Activation	hsa01521
In Vitro Model	Jurkat cells	Pleural effusion	Homo sapiens (Human)	CVCL_0065
	CCRF-CEM cells	Pleural effusion	Homo sapiens (Human)	CVCL_0207
Experiment for Molecule Alteration	Western blot analysis; RT-qPCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEk/ERk pathway.

Prednisone

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Acute lymphocytic leukemia				[1]
Resistant Disease	Acute lymphocytic leukemia [ICD-11: 2B33.0]			Disease Info
Resistant Drug	Prednisone			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Revealed Based on the Cell Line Data
Cell Pathway Regulation	Cell apoptosis		Inhibition	hsa04210
	Cell proliferation		Activation	hsa05200
	EGFR/RAS/RAF/MEK/ERK signaling pathway		Activation	hsa01521
In Vitro Model	Jurkat cells	Pleural effusion	Homo sapiens (Human)	CVCL_0065
	CCRF-CEM cells	Pleural effusion	Homo sapiens (Human)	CVCL_0207
Experiment for Molecule Alteration	Western blot analysis; RT-qPCR
Experiment for Drug Resistance	CCK8 assay; Flow cytometry assay
Mechanism Description	TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEk/ERk pathway.

References

Ref 1	TCF7L2 activated HOXA-AS2 decreased the glucocorticoid sensitivity in acute lymphoblastic leukemia through regulating HOXA3/EGFR/Ras/Raf/MEK/ERK pathway. Biomed Pharmacother. 2019 Jan;109:1640-1649. doi: 10.1016/j.biopha.2018.10.046. Epub 2018 Nov 16.