Molecule Information

General Information of the Molecule (ID: Mol00412)

Name	Nucleosome-binding protein 1 (NSBP1) ,Homo sapiens
Synonyms	Nucleosome-binding protein 1; NSBP1 Click to Show/Hide
Molecule Type	Protein
Gene Name	HMGN5
Gene ID	79366
Location	chrX:81113699-81201913[-]
Sequence	MPKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSA QAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVA AEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGE DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKE DEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV Click to Show/Hide
Function	Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction. Click to Show/Hide
Uniprot ID	HMGN5_HUMAN
Ensembl ID	ENSG00000198157
HGNC ID	HGNC:8013
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Doxorubicin

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Osteosarcoma				[1]
Resistant Disease	Osteosarcoma [ICD-11: 2B51.0]			Disease Info
Resistant Drug	Doxorubicin			Drug Info
Molecule Alteration	Expression		Up-regulation
Experimental Note	Identified from the Human Clinical Data
Cell Pathway Regulation	Cell autophagy		Activation	hsa04140
In Vitro Model	MG63 cells	Bone marrow	Homo sapiens (Human)	CVCL_0426
	U2OS cells	Bone	Homo sapiens (Human)	CVCL_0042
	hFOB1.19 cells	Fetal bone	Homo sapiens (Human)	CVCL_3708
In Vivo Model	Nude mouse xenograft model			Mus musculus
Experiment for Molecule Alteration	Luciferase activity assay; Western blot analysis
Experiment for Drug Resistance	IC50 assay; Flow cytometric analysis
Mechanism Description	miR140-5p/HMGN5/autophagy regulatory loop plays a critical role in chemoresistance in osteosarcoma, miR 140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy.

References

Ref 1	MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy. Sci Rep. 2017 Mar 24;7(1):416. doi: 10.1038/s41598-017-00405-3.