Molecule Information

General Information of the Molecule (ID: Mol00364)

Name	NUP98-DDX10 fusion protein type 1 (NUP98-DDX10 ) ,Homo sapiens
Synonyms	PTSG_00124; NUP98-DDX10 fusion protein type 1 Click to Show/Hide
Molecule Type	Protein
Gene Name	PTSG_00124
Gene ID	16067821
Sequence	MGRKGNKKQHVADAADADVKEEEVESTPTPQPTPSALPLEATANAGEWERLTHSDGTPLK LDERILTRLRAWKFDQMTPVQAACVPLFLEYKDVAAEAVTGSGKTLAFLIPAVEMLLRTP PKSRMAVGCIVLSPTRELAQQTHHVLSDLLKDSPLTHVLITGGKDAETDIVSMEKHGTNI IVATPGRLNDLIKRVPSLATNIKLLEVFVMDEADRLLDMGFKTTLNEILAVLPKQRRTGL FSATQTKEVELLVRAGLRNPVRVTVAVEDPEMFVHRCGRTARNGLDGNALLYLMPTEDEY VEFLKIRQVPMEEMDAITAAPSQFSAVRTHAANDRDIYEKGRLAFVSYIRSYREHKCNFL LKLSRLDLGMVANGFGLLDLPVMPELKKSKAAANFVPSDVDTSAITFKDKNREKQRQENL KRRGDRTSDPAAKRSKERQKQKNEAWSKQKERKKKKLARATKKQQQEDRKRKKMLENLLE TEQEWDELAREVRLRKQLKQGKITQDEFERLVGEDADPVMTM Click to Show/Hide
Uniprot ID	F2TVL2_SALR5
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Imatinib

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Disease Class: Chronic myeloid leukemia				[1]
Resistant Disease	Chronic myeloid leukemia [ICD-11: 2A20.0]			Disease Info
Resistant Drug	Imatinib			Drug Info
Molecule Alteration	Structural mutation		Structural variation
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	K562 cells	Blood	Homo sapiens (Human)	CVCL_0004
Experiment for Molecule Alteration	RT-PCR analysis
Experiment for Drug Resistance	Western blot analysis with anti-CrkL antibody assay
Mechanism Description	Collectively, these observations raise the possibility that NUP98/DDX10 might have played a role not only in disease progression but also in the acquisition of resistance to imatinib.

References

Ref 1	Clonal evolution with inv(11)(p15q22) and NUP98/DDX10 fusion gene in imatinib-resistant chronic myelogenous leukemia. Cancer Genet Cytogenet. 2005 Mar;157(2):104-8. doi: 10.1016/j.cancergencyto.2004.06.014.