Molecule Information

General Information of the Molecule (ID: Mol00189)

Name	Thyroid receptor-interacting protein 6 (TRIP6) ,Homo sapiens
Synonyms	TR-interacting protein 6; TRIP-6; Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1; OIP1 Click to Show/Hide
Molecule Type	Protein
Gene Name	TRIP6
Gene ID	7205
Location	chr7:100867387-100873454[+]
Sequence	MSGPTWLPPKQPEPARAPQGRAIPRGTPGPPPAHGAALQPHPRVNFCPLPSEQCYQAPGG PEDRGPAWVGSHGVLQHTQGLPADRGGLRPGSLDAEIDLLSSTLAELNGGRGHASRRPDR QAYEPPPPPAYRTGSLKPNPASPLPASPYGGPTPASYTTASTPAGPAFPVQVKVAQPVRG CGPPRRGASQASGPLPGPHFPLPGRGEVWGPGYRSQREPGPGAKEEAAGVSGPAGRGRGG EHGPQVPLSQPPEDELDRLTKKLVHDMNHPPSGEYFGQCGGCGEDVVGDGAGVVALDRVF HVGCFVCSTCRAQLRGQHFYAVERRAYCEGCYVATLEKCATCSQPILDRILRAMGKAYHP GCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVA LDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC Click to Show/Hide
Function	Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. Click to Show/Hide
Uniprot ID	TRIP6_HUMAN
Ensembl ID	ENSG00000087077
HGNC ID	HGNC:12311
*Click to Show/Hide the Complete Species Lineage*
Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens

Type(s) of Resistant Mechanism of This Molecule

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s)

1 drug(s) in total

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Pazopanib HCl

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Disease Class: Synovial sarcoma				[1]
Resistant Disease	Synovial sarcoma [ICD-11: 2B5A.0]			Disease Info
Resistant Drug	Pazopanib HCl			Drug Info
Molecule Alteration	Expression		Down-regulation
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	1273/99 cells	Sarcoma	Homo sapiens (Human)	CVCL_N588
	HS-SYII cells	Sarcoma	Homo sapiens (Human)	CVCL_8719
	SYO-1 cells	Sarcoma	Homo sapiens (Human)	CVCL_7146
	YaFuSS cells	Sarcoma	Homo sapiens (Human)	CVCL_L809
Experiment for Molecule Alteration	qRT-PCR
Experiment for Drug Resistance	EV isolation, immunoblotting, and nanoparticle tracking analysis
Mechanism Description	Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma by down-regulating TRIP6, LMNA, and SIRT3 expression.

References

Ref 1	Extracellular vesicle-encapsulated microRNA-761 enhances pazopanib resistance in synovial sarcoma. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1322-1327. doi: 10.1016/j.bbrc.2017.11.164. Epub 2017 Nov 27.