Drug Information

Drug (ID: DG01900) and It's Reported Resistant Information

Name	hEGFR vIII-CD3 bi-scFv
Synonyms	HEGFRvIII-CD3 bi-scFv Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Brain cancer [ICD-11: 2A00]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Epidermal growth factor receptor (EGFR)				[1]
Molecule Alteration	Complex-indel		(c.89_889del11867)	Molecule Info
Sensitive Disease	Brain glioma [ICD-11: 2A00.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	U87-MG cells	Brain	Homo sapiens (Human)	CVCL_0022
Experiment for Drug Resistance	Chromium release assay; FACS assay

References

Ref 1	A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant GliomaClin Cancer Res. 2018 Aug 1;24(15):3611-3631. doi: 10.1158/1078-0432.CCR-17-0126. Epub 2018 Apr 27.

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