Drug Information

Drug (ID: DG01866) and It's Reported Resistant Information
Name
Compound 3144
Synonyms
Compound 3144
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Target . NOUNIPROTAC [1]
Type(s) of Resistant Mechanism of This Drug
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Mature T-cell lymphoma [ICD-11: 2A90]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: GTPase Nras (NRAS) [1]
Molecule Alteration Missense mutation
p.G13D (c.38G>A)
 Molecule Info 
Sensitive Disease T-cell lymphoma [ICD-11: 2A60.3]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation RAS signaling pathway Inhibition hsa04014
In Vitro Model MEF cells Bone marrow Homo sapiens (Human) CVCL_M515
In Vivo Model Athymic nude Nu/Nu mouse PDX model Mus musculus
References
Ref 1 Multivalent Small-Molecule Pan-RAS InhibitorsCell. 2017 Feb 23;168(5):878-889.e29. doi: 10.1016/j.cell.2017.02.006.

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