Drug Information

Drug (ID: DG01860) and It's Reported Resistant Information

Name	Unspecified VEGFR2 antibody
Synonyms	Unspecified VEGFR2 antibody Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

RTDM: Regulation by the Disease Microenvironment

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Melanoma [ICD-11: 2C30]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Regulation by the Disease Microenvironment (RTDM)			Click to Show/Hide
Key Molecule: VEGF-2 receptor (KDR)				[1]
Molecule Alteration	Missense mutation		p.Q472H (c.1416A>T)	Molecule Info
Sensitive Disease	Melanoma [ICD-11: 2C30.0]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	WM3248 cells	Skin	Homo sapiens (Human)	CVCL_6798
	WM1575 cells	Skin	Homo sapiens (Human)	CVCL_L027
Experiment for Molecule Alteration	Targeted NGS assay
Experiment for Drug Resistance	Proliferation assay; Invasion assay

References

Ref 1	Identification of a Novel Pathogenic Germline KDR Variant in MelanomaClin Cancer Res. 2016 May 15;22(10):2377-85. doi: 10.1158/1078-0432.CCR-15-1811. Epub 2015 Dec 2.

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