Drug Information

Drug (ID: DG01843) and It's Reported Resistant Information

Name	Chembl2042164
Synonyms	CHEMBL2042164; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl]tetrahydrofuran-3,4-diol; BDBM50524391; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(4-phenylpiperazin-1-yl)-9H-purin-9-yl]tetrahydrofuran-3,4-diol (non-preferred name); (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(4-phenylpiperazin-1-yl)purin-9-yl]tetrahydrofuran-3,4-diol; ERS Click to Show/Hide
Structure
Drug Resistance Disease(s)	*Disease(s) with Resistance Information Validated by in-vivo* Model for This Drug** (1 diseases) Myocardial infarction [ICD-11: BA41] [1]
Target	.	NOUNIPROTAC	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	4
IsoSMILES	C1CN(CCN1C2=CC=CC=C2)C3=NC=NC4=C3N=CN4[C@H]5[C@@H]([C@@H]([C@H](O5)CO)O)O
InChI	InChI=1S/C20H24N6O4/c27-10-14-16(28)17(29)20(30-14)26-12-23-15-18(21-11-22-19(15)26)25-8-6-24(7-9-25)13-4-2-1-3-5-13/h1-5,11-12,14,16-17,20,27-29H,6-10H2/t14-,16-,17-,20-/m1/s1
InChIKey	FVRJZHPJEJJPPT-WVSUBDOOSA-N
PubChem CID	44776615

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-11: Circulatory system diseases

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Myocardial infarction [ICD-11: BA41]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Maternally expressed 3 (MEG3)				[1]
Molecule Alteration	Up-regulation		Interaction	Molecule Info
Resistant Disease	Myocardial infarction [ICD-11: BA41.0]			Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Primary neonatal mice ventricular myocytes	N.A.	.	N.A.
In Vivo Model	C57/BL6J mice myocardial infarction model			Mus musculus
Experiment for Molecule Alteration	qRT-PCR; Knockdown assay
Mechanism Description	Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarction.

References

Ref 1	Long non-coding RNA MEG3 knockdown attenuates endoplasmic reticulum stress-mediated apoptosis by targeting p53 following myocardial infarctionJ Cell Mol Med. 2019 Dec;23(12):8369-8380. doi: 10.1111/jcmm.14714. Epub 2019 Oct 20.