Drug Information

Drug (ID: DG01832) and It's Reported Resistant Information

• Name: Polyphyllin I
• Synonyms: Polyphyllin I; 50773-41-6; (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)-2-[(1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol; CHEMBL3931203; HY-N0047; NSC805340; s9114; AKOS037515173; ZINC252491736; CCG-270534; NSC-805340; CS-0007105
• Drug Resistance Disease(s):
  Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
  Nasopharyngeal cancer [ICD-11: 2B6B]; [1]
• Target: .; NOUNIPROTAC; [1]
• Formula: 8
• IsoSMILES: C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO)O[C@H]8[C@@H]([C@H]([C@@H](O8)CO)O)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)C)C)C)OC1
• InChI: InChI=1S/C44H70O16/c1-19-8-13-44(53-18-19)20(2)30-27(60-44)15-26-24-7-6-22-14-23(9-11-42(22,4)25(24)10-12-43(26,30)5)55-41-38(59-39-35(51)33(49)31(47)21(3)54-39)36(52)37(29(17-46)57-41)58-40-34(50)32(48)28(16-45)56-40/h6,19-21,23-41,45-52H,7-18H2,1-5H3/t19-,20+,21+,23+,24-,25+,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36+,37-,38-,39+,40+,41-,42+,43+,44-/m1/s1
• InChIKey: LRRDDWMXYOSKIC-IPKCVOQPSA-N
• PubChem CID: 11018329

Type(s) of Resistant Mechanism of This Drug

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Nasopharyngeal cancer [ICD-11: 2B6B]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Long non-protein coding RNA, regulator of reprogramming (LINC-ROR) [1]

• Molecule Alteration: Up-regulation; Expression
• Resistant Disease: Nasopharyngeal carcinoma [ICD-11: 2B6B.0]
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: CNE-2 cells; Nasopharynx; Homo sapiens (Human); CVCL_6888
• In Vitro Model: CNE-1 cells; N.A.; Homo sapiens (Human); CVCL_6888
• In Vitro Model: HONE-1 cells; Nasopharynx; Homo sapiens (Human); CVCL_8706
• In Vitro Model: HNE-1 cells; Nasopharynx; Homo sapiens (Human); CVCL_0308
• In Vivo Model: BALB/c nude mice model; Mus musculus
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: Anticancer activity of polyphyllin I in nasopharyngeal carcinoma by modulation of LncRNA ROR and P53 signalling.

References

• Ref 1: Anticancer activity of polyphyllin I in nasopharyngeal carcinoma by modulation of lncRNA ROR and P53 signallingJ Drug Target. 2019 Aug;27(7):806-811. doi: 10.1080/1061186X.2018.1561887. Epub 2019 Feb 11.