Drug (ID: DG01815) and It's Reported Resistant Information
Name
5-Ethynyl-2'-deoxyuridine
Synonyms
5-Ethynyl-2'-deoxyuridine; 61135-33-9; 2'-Deoxy-5-ethynyluridine; 5-Ethynyl-2'-dU; Uridine, 2'-deoxy-5-ethynyl-; UNII-G373S00W2J; EdU (5-ethynyl-2'-deoxyuridine); G373S00W2J; MFCD01675687; 5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-Ethynyl-2'-deoxyuridine; 5-Ethynyl-dUrd; 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 5-Ethynyl-dU; EDU; BRN 0756841; 5-EdU; 2'deoxy-5-ethynyluridine; EdU (ethynyldeoxyuridine); SCHEMBL868882; CHEMBL222932; DTXSID20976652; ZINC3794605; s1661; AKOS024462948; 5-Ethynyl-2'-deoxy-uridine (5-EdU); AC-32360; AS-59368; HY-118411; CS-0065850; C75857; 5-Ethynyl-2'-deoxyuridine, (EdU), AldrichCPR; J-700091; J-700347; Q4639590; 1-(2-Deoxypentofuranosyl)-5-ethynyl-4-hydroxypyrimidin-2(1H)-one; 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
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Structure
Drug Resistance Disease(s)
Disease(s) with Resistance Information Discovered by Cell Line Test for This Drug (1 diseases)
Breast cancer [ICD-11: 2C60]
[1]
Target . NOUNIPROTAC [1]
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Formula
3
IsoSMILES
C#CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
InChI
InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
InChIKey
CDEURGJCGCHYFH-DJLDLDEBSA-N
PubChem CID
472172
Type(s) of Resistant Mechanism of This Drug
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Click to Show/Hide the Resistance Disease of This Class
Breast cancer [ICD-11: 2C60]
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: Nuclear paraspeckle assembly transcript 1 (NEAT1) [1]
Molecule Alteration Up-regulation
Interaction
Resistant Disease Breast adenocarcinoma [ICD-11: 2C60.1]
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model MDA-MB-231 cells Breast Homo sapiens (Human) CVCL_0062
MDA-MB-468 cells Breast Homo sapiens (Human) CVCL_0419
BT-549 cells Breast Homo sapiens (Human) CVCL_1092
MF-7 cells N.A. . N.A.
Experiment for
Molecule Alteration
Western bloting analysis; qRT-PCR; Overexpression assay
Experiment for
Drug Resistance
EdU assay
Mechanism Description Identification of LncRNA NEAT1/miR-21/RRM2 axis as a novel biomarker in breast cancer.
References
Ref 1 NEAT1 regulates MPP(+)-induced neuronal injury by targeting miR-124 in neuroblastoma cellsNeurosci Lett. 2019 Aug 24;708:134340. doi: 10.1016/j.neulet.2019.134340. Epub 2019 Jun 19.

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