Drug Information

Drug (ID: DG01729) and It's Reported Resistant Information

• Name: Unspecified CTLA4 antibody/Unspecified PD-1 antibody
• Synonyms: Unspecified CTLA4 antibody/unspecified PD-1 antibody
• Drug Resistance Disease(s):
  Disease(s) with Clinically Reported Resistance for This Drug (1 diseases)
  Lung cancer [ICD-11: 2C25]; [1]
• Target: .; NOUNIPROTAC; [1]

Type(s) of Resistant Mechanism of This Drug

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Lung cancer [ICD-11: 2C25]

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Epidermal growth factor receptor (EGFR) [1]

• Molecule Alteration: Missense mutation; p.L858R (c.2573T>G)
• Resistant Disease: Lung adenocarcinoma [ICD-11: 2C25.0]
• Experimental Note: Identified from the Human Clinical Data

References

• Ref 1: EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small-cell lung cancerAnn Oncol. 2019 Aug 1;30(8):1311-1320. doi: 10.1093/annonc/mdz141.