Drug Information

Drug (ID: DG01719) and It's Reported Resistant Information

Name	Irinotecan/Selumetinib
Synonyms	Irinotecan/Selumetinib Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)		Click to Show/Hide
Key Molecule: GTPase KRas (KRAS)			[1]
Molecule Alteration	IF-deletion	p.M1_E37 (c.1-11_111)	Molecule Info
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Colon		N.A.
Experiment for Drug Resistance	Tumor evaluation assay

References

Ref 1	Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancerCancer Chemother Pharmacol. 2015 Jan;75(1):17-23. doi: 10.1007/s00280-014-2609-3. Epub 2014 Oct 17.

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