Drug Information

Drug (ID: DG01711) and It's Reported Resistant Information

Name	Crenolanib/Trametinib
Synonyms	Crenolanib/Trametinib Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Hematologic cancer [ICD-11: 2B3Z]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Aberration of the Drug's Therapeutic Target (ADTT)			Click to Show/Hide
Key Molecule: Receptor-type tyrosine-protein kinase FLT3 (FLT3)				[1]
Molecule Alteration	Missense mutation		p.D835Y (c.2503G>T)	Molecule Info
Sensitive Disease	Hematologic Cancer [ICD-11: MG24.Y]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Ba/F3 cells	Colon	Homo sapiens (Human)	CVCL_0161
	HEK 293T cells	Kidney	Homo sapiens (Human)	CVCL_0063
Experiment for Molecule Alteration	Whole exome sequencing
Experiment for Drug Resistance	MTS assay

References

Ref 1	Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanismsNat Commun. 2019 Jan 16;10(1):244. doi: 10.1038/s41467-018-08263-x.

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