Drug Information

Drug (ID: DG01677) and It's Reported Resistant Information

Name	Bevacizumab/FOLFIRI Regimen
Synonyms	Bevacizumab/FOLFIRI Regimen Click to Show/Hide
Target	.	NOUNIPROTAC	[1]

Type(s) of Resistant Mechanism of This Drug

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

Click to Show/Hide the Resistance Disease of This Class

Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)				[1]
Molecule Alteration	Missense mutation		p.R251P (c.752G>C)	Molecule Info
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	HT29 Cells	Colon	Homo sapiens (Human)	CVCL_A8EZ
	HT29 Cells	Colon	Homo sapiens (Human)	CVCL_A8EZ
	SW480 cells	Colon	Homo sapiens (Human)	CVCL_0546
	HCT116 cells	Colon	Homo sapiens (Human)	CVCL_0291
In Vivo Model	BALB/c nude mouse PDX model			Mus musculus
Experiment for Drug Resistance	MTT assay

References

Ref 1	Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancerJ Cancer Res Clin Oncol. 2016 Aug;142(8):1705-14. doi: 10.1007/s00432-016-2177-5. Epub 2016 May 13.

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