Drug Information
Drug (ID: DG01658) and It's Reported Resistant Information
| Name |
NTRC 0066-0
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| Synonyms |
NTRC-0066-0; NTRC 0066-0; 1817791-73-3; JGS79C; CHEMBL4449557; SCHEMBL18163318; BDBM532292; US11208696, Example 11; NSC794589; NSC-794589; SB19776; HY-100024; CS-0017983; E77323; N-(2,6-diethylphenyl)-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide; N66
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| Structure |
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| Target | . | NOUNIPROTAC | [1] | ||
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| Formula |
8
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| IsoSMILES |
CCC1=C(C(=CC=C1)CC)NC(=O)C2=C3CCC4=CN=C(N=C4N3C=C2)NC5=C(C=C(C=C5)N6CCN(CC6)C)OC
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| InChI |
InChI=1S/C33H39N7O2/c1-5-22-8-7-9-23(6-2)30(22)36-32(41)26-14-15-40-28(26)13-10-24-21-34-33(37-31(24)40)35-27-12-11-25(20-29(27)42-4)39-18-16-38(3)17-19-39/h7-9,11-12,14-15,20-21H,5-6,10,13,16-19H2,1-4H3,(H,36,41)(H,34,35,37)
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| InChIKey |
HGEIUFJVGHMGRR-UHFFFAOYSA-N
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| PubChem CID | |||||
Type(s) of Resistant Mechanism of This Drug
UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
Colon cancer [ICD-11: 2B90]
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
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Unusual Activation of Pro-survival Pathway (UAPP)
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| Key Molecule: Catenin beta-1 (CTNNB1) | [1] | |||
| Molecule Alteration | IF-deletion | p.S45delS (c.133_135delTCT) |
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| Sensitive Disease | Colon cancer [ICD-11: 2B90.1] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 |
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | |
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | |
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | |
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | |
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | |
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | |
| In Vivo Model | Mouse xenograft model | Mus musculus | ||
| Experiment for Molecule Alteration |
Gene set analysis | |||
| Experiment for Drug Resistance |
Cell proliferation assay | |||
| Mechanism Description | The if-deletion p.S45delS (c.133_135delTCT) in gene CTNNB1 cause the sensitivity of NTRC 0066-0 by unusual activation of pro-survival pathway. | |||
Colorectal cancer [ICD-11: 2B91]
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
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Unusual Activation of Pro-survival Pathway (UAPP)
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| Key Molecule: Catenin beta-1 (CTNNB1) | [1] | |||
| Molecule Alteration | Missense mutation | p.S45F (c.134C>T) |
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| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 |
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | |
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | |
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | |
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | |
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | |
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | |
| In Vivo Model | Mouse xenograft model | Mus musculus | ||
| Experiment for Molecule Alteration |
Gene set analysis | |||
| Experiment for Drug Resistance |
Cell proliferation assay | |||
| Mechanism Description | The missense mutation p.S45F (c.134C>T) in gene CTNNB1 cause the sensitivity of NTRC 0066-0 by unusual activation of pro-survival pathway | |||
| Key Molecule: Catenin beta-1 (CTNNB1) | [1] | |||
| Molecule Alteration | Missense mutation | p.S33Y (c.98C>A) |
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| Sensitive Disease | Colorectal cancer [ICD-11: 2B91.1] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 |
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | |
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | |
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | |
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | |
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | |
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | |
| In Vivo Model | Mouse xenograft model | Mus musculus | ||
| Experiment for Molecule Alteration |
Gene set analysis | |||
| Experiment for Drug Resistance |
Cell proliferation assay | |||
| Mechanism Description | The missense mutation p.S33Y (c.98C>A) in gene CTNNB1 cause the sensitivity of NTRC 0066-0 by unusual activation of pro-survival pathway | |||
Lung cancer [ICD-11: 2C25]
| Drug Sensitivity Data Categorized by Their Corresponding Mechanisms | ||||
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Unusual Activation of Pro-survival Pathway (UAPP)
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| Key Molecule: Catenin beta-1 (CTNNB1) | [1] | |||
| Molecule Alteration | Missense mutation | p.T41A (c.121A>G) |
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| Sensitive Disease | Lung adenocarcinoma [ICD-11: 2C25.0] | |||
| Experimental Note | Revealed Based on the Cell Line Data | |||
| In Vitro Model | HCT116 cells | Colon | Homo sapiens (Human) | CVCL_0291 |
| SW48 cells | Colon | Homo sapiens (Human) | CVCL_1724 | |
| TOV-21G cells | Ovary | Homo sapiens (Human) | CVCL_3613 | |
| HuTu80 cells | Small intestine | Homo sapiens (Human) | CVCL_1301 | |
| TOV-112D cells | Ovary | Homo sapiens (Human) | CVCL_3612 | |
| LS 174T cells | Colon | Homo sapiens (Human) | CVCL_1384 | |
| A427 cells | Lung | Homo sapiens (Human) | CVCL_1055 | |
| In Vivo Model | Mouse xenograft model | Mus musculus | ||
| Experiment for Molecule Alteration |
Gene set analysis | |||
| Experiment for Drug Resistance |
Cell proliferation assay | |||
| Mechanism Description | The missense mutation p.T41A (c.121A>G) in gene CTNNB1 cause the sensitivity of NTRC 0066-0 by unusual activation of pro-survival pathway | |||
References
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