Drug Information

Drug (ID: DG01528) and It's Reported Resistant Information

Name	JW74
Synonyms	JW74; 863405-60-1; CHEMBL1552719; JW-74; 5-(((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole; SCHEMBL11919898; HMS1844M08; JW 74; ZINC8614303; BDBM50380592; CCG-68686; STL406359; AKOS001512198; CS-5463; MCULE-3805212654; JW74, >=98% (HPLC); NCGC00115449-01; NCGC00115449-04; HY-19739; D065-0024; 3-(4-Methylphenyl)-5-[[[4-(4-methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazole-3-yl]thio]methyl]-1,2,4-oxadiazole; 4-[4-(4-methoxyphenyl)-5-({[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}sulfanyl)-4H-1,2,4-triazol-3-yl]pyridine; 4-[4-(4-methoxyphenyl)-5-({[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl}thio)-4H-1,2,4-triazol-3-yl]pyridine; 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine; 5-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanylmethyl]-3-(4-methylphenyl)-1,2,4-oxadiazole Click to Show/Hide
Structure
Target	.	NOUNIPROTAC	[1]
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Formula	7
IsoSMILES	CC1=CC=C(C=C1)C2=NOC(=N2)CSC3=NN=C(N3C4=CC=C(C=C4)OC)C5=CC=NC=C5
InChI	InChI=1S/C24H20N6O2S/c1-16-3-5-17(6-4-16)22-26-21(32-29-22)15-33-24-28-27-23(18-11-13-25-14-12-18)30(24)19-7-9-20(31-2)10-8-19/h3-14H,15H2,1-2H3
InChIKey	KRIKILRRJCIWNB-UHFFFAOYSA-N
PubChem CID	16013152

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Adenomatous polyposis coli protein (APC)				[1]
Molecule Alteration	Nonsense		p.Q1338* (c.4012C>T)	Molecule Info
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HEK293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
Mechanism Description	The nonsense p.Q1338* (c.4012C>T) in gene APC cause the sensitivity of JW74 by unusual activation of pro-survival pathway.

References

Ref 1	Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growthCancer Res. 2011 Jan 1;71(1):197-205. doi: 10.1158/0008-5472.CAN-10-1282.