Drug Information

Drug (ID: DG01480) and It's Reported Resistant Information

Name	JW67
Synonyms	JW 67; 442644-28-2; JW67; CHEMBL1459534; SMR000013289; Trispiro[3H-indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione (9CI); trispiro[indole-3,2'-[1,3]dioxane-5',5''-[1,3]dioxane-2'',3'''-indole]-2,2'''(1H,1'''H)-dione; ChemDiv1_018326; Oprea1_749592; MLS000076453; MLS001385179; SCHEMBL21843254; HMS639A22; HMS2324F10; HMS3429N11; JW-67; ZINC4126706; BDBM50380615; STK056247; AKOS000550561; CID 644733; JW67, >=98% (HPLC); HY-108442; CS-0028671; SR-01000537125; SR-01000537125-1; Trispiro[3H-indole-3,2'-[1,3]dioxane-2'',3'''-[3H]indole]-2,2'''(1H,1'''H)-dione Click to Show/Hide
Structure
Target	.	NOUNIPROTAC	[1]
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IsoSMILES	C1C2(COC3(O1)C4=CC=CC=C4NC3=O)COC5(C6=CC=CC=C6NC5=O)OC2
InChI	InChI=1S/C21H18N2O6/c24-17-20(13-5-1-3-7-15(13)22-17)26-9-19(10-27-20)11-28-21(29-12-19)14-6-2-4-8-16(14)23-18(21)25/h1-8H,9-12H2,(H,22,24)(H,23,25)
InChIKey	BTXRSHKJNDFHGA-UHFFFAOYSA-N
PubChem CID	644733

Type(s) of Resistant Mechanism of This Drug

UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-02: Benign/in-situ/malignant neoplasm

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Colorectal cancer [ICD-11: 2B91]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Unusual Activation of Pro-survival Pathway (UAPP)			Click to Show/Hide
Key Molecule: Adenomatous polyposis coli protein (APC)				[1]
Molecule Alteration	Nonsense		p.Q1338* (c.4012C>T)	Molecule Info
Sensitive Disease	Colorectal cancer [ICD-11: 2B91.1]			Disease Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	HEK293 cells	Kidney	Homo sapiens (Human)	CVCL_0045
Mechanism Description	The nonsense p.Q1338* (c.4012C>T) in gene APC cause the sensitivity of JW67 by unusual activation of pro-survival pathway.

References

Ref 1	Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growthCancer Res. 2011 Jan 1;71(1):197-205. doi: 10.1158/0008-5472.CAN-10-1282.