Drug Information

Drug (ID: DG00863) and It's Reported Resistant Information

• Name: Lucanthone
• Synonyms: LUCANTHONE; 479-50-5; Lucanthon; Lucanthonum; Lucantona; Lucanthonum [INN-Latin]; Lucantona [INN-Spanish]; 1-((2-(Diethylamino)ethyl)amino)-4-methylthioxanthen-9-one; 1-{[2-(Diethylamino)ethyl]amino}-4-methyl-9H-thioxanthen-9-one; UNII-FC6D57000M; CHEBI:51052; 1-((2-(diethylamino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one; FC6D57000M; Lucanthone [INN:BAN]; 1-[[2-(Diethylamino)ethyl]amino]-4-methylthioxanthone; 1-diethylaminoethylethylamino-4-methyl-thioxanthenone; 1-{[2-(diethylamino)ethyl]amino}-4-methylthioxanthen-9-one; NSC14574; CCRIS 1106; EINECS 207-532-4; BRN 0312369; AI3-16160; NCIMech_000830; SCHEMBL9156; 5-18-11-00503 (Beilstein Handbook Reference); CHEMBL279014; DTXSID6023230; HY-B2098; Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl-; ZINC3831012; 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-; BDBM50030282; CCG-35817; s6471; CS-6665; DB04967; BS-49111; NCI60_000988; 479L505; Q6696022; 1-(2-diethylaminoethylamino)-4-methyl-thioxanthen-9-one; 1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one; 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-methyl- (9CI)
• Indication:
  In total 1 Indication(s)
  Solid tumour/cancer [ICD-11: 2A00-2F9Z]; Approved; [1]
• Target: DNA topoisomerase II (TOP2); TOP2A_HUMAN TOP2B_HUMAN; [1]
• Formula: C20H24N2OS
• IsoSMILES: CCN(CC)CCNC1=C2C(=C(C=C1)C)SC3=CC=CC=C3C2=O
• InChI: 1S/C20H24N2OS/c1-4-22(5-2)13-12-21-16-11-10-14(3)20-18(16)19(23)15-8-6-7-9-17(15)24-20/h6-11,21H,4-5,12-13H2,1-3H3
• InChIKey: FBQPGGIHOFZRGH-UHFFFAOYSA-N
• PubChem CID: 10180
• ChEBI ID: CHEBI:51052
• TTD Drug ID: D09OZC
• DrugBank ID: DB04967

References

• Ref 1: Quinolizidine-Derived Lucanthone and Amitriptyline Analogues Endowed with Potent Antileishmanial Activity .Pharmaceuticals (Basel). 2020 Oct 25;13(11):339. doi: 10.3390/ph13110339. 10.3390/ph13110339