Drug Information

Drug (ID: DG00624) and It's Reported Resistant Information
Name
Ceragenin
Synonyms
Ceragenin CSA-13; CSA-13; CHEMBL1275763; SCHEMBL14816571; 222022-08-4
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Indication
In total 1 Indication(s)
Bacterial infection [ICD-11: 1A00-1C4Z]
Investigative
[1]
Structure
Target . NOUNIPROTAC [1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula
C41H80N4O3
IsoSMILES
CCCCCCCCNCCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)OCCCN)C)OCCCN)OCCCN)C
InChI
1S/C41H80N4O3/c1-5-6-7-8-9-10-23-45-24-11-15-31(2)34-16-17-35-39-36(30-38(41(34,35)4)48-27-14-22-44)40(3)19-18-33(46-25-12-20-42)28-32(40)29-37(39)47-26-13-21-43/h31-39,45H,5-30,42-44H2,1-4H3/t31-,32+,33-,34-,35+,36+,37-,38+,39+,40+,41-/m1/s1
InChIKey
YDYLISNLJUDIGF-GXDYCHSMSA-N
PubChem CID
16678119
TTD Drug ID
D05GQD
Type(s) of Resistant Mechanism of This Drug
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-10: Ear/mastoid process diseasess
Click to Show/Hide the Resistance Disease of This Class
Otitis media [ICD-11: AA80]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: Interleukin-8 (IL8) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Otitis media [ICD-11: AA80.0]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation IL-8 pathway Regulation hsa04622
In Vitro Model Streptococcus pneumoniae ATCC 49619 1313
Experiment for
Molecule Alteration		 ELISA assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Immobilization of ceragenins on the surface of nonspherical gold nanoparticles intensifies their antibacterial effects, against both planktonic and biofilm form of bacteria. At the same time, it reduces the secretion of IL-8 and reduces the inflammatory response.
Key Molecule: Interleukin-8 (IL8) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Otitis media [ICD-11: AA80.0]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation IL-8 pathway Regulation hsa04622
In Vitro Model Streptococcus pneumoniae ATCC 49619 1313
Experiment for
Molecule Alteration		 ELISA assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Immobilization of ceragenins on the surface of nonspherical gold nanoparticles intensifies their antibacterial effects, against both planktonic and biofilm form of bacteria. At the same time, it reduces the secretion of IL-8 and reduces the inflammatory response.
Key Molecule: Interleukin-8 (IL8) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Otitis media [ICD-11: AA80.0]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation IL-8 pathway Regulation hsa04622
In Vitro Model Moraxella catarrhalis ATCC 25238 480
Experiment for
Molecule Alteration		 ELISA assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Immobilization of ceragenins on the surface of nonspherical gold nanoparticles intensifies their antibacterial effects, against both planktonic and biofilm form of bacteria. At the same time, it reduces the secretion of IL-8 and reduces the inflammatory response.
Key Molecule: Interleukin-8 (IL8) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Otitis media [ICD-11: AA80.0]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation IL-8 pathway Regulation hsa04622
In Vitro Model Moraxella catarrhalis ATCC 25238 480
Experiment for
Molecule Alteration		 ELISA assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Immobilization of ceragenins on the surface of nonspherical gold nanoparticles intensifies their antibacterial effects, against both planktonic and biofilm form of bacteria. At the same time, it reduces the secretion of IL-8 and reduces the inflammatory response.
Key Molecule: Interleukin-8 (IL8) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Otitis media [ICD-11: AA80.0]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation IL-8 pathway Regulation hsa04622
In Vitro Model Haemophilus influenzae ATCC 49766 727
Experiment for
Molecule Alteration		 ELISA assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Immobilization of ceragenins on the surface of nonspherical gold nanoparticles intensifies their antibacterial effects, against both planktonic and biofilm form of bacteria. At the same time, it reduces the secretion of IL-8 and reduces the inflammatory response.
Key Molecule: Interleukin-8 (IL8) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Otitis media [ICD-11: AA80.0]
 Disease Info 
Experimental Note Discovered Using In-vivo Testing Model
Cell Pathway Regulation IL-8 pathway Regulation hsa04622
In Vitro Model Haemophilus influenzae ATCC 49766 727
Experiment for
Molecule Alteration		 ELISA assay
Experiment for
Drug Resistance		 Broth microdilution method assay
Mechanism Description Immobilization of ceragenins on the surface of nonspherical gold nanoparticles intensifies their antibacterial effects, against both planktonic and biofilm form of bacteria. At the same time, it reduces the secretion of IL-8 and reduces the inflammatory response.
References
Ref 1 Targeting bacteria causing otitis media using nanosystems containing nonspherical gold nanoparticles and ceragenins .Nanomedicine (Lond). 2021 Dec;16(30):2657-2678. doi: 10.2217/nnm-2021-0370. Epub 2021 Nov 26. 10.2217/nnm-2021-0370

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