Drug Information

Drug (ID: DG00396) and It's Reported Resistant Information

Name	Bisbenzimide (Hoechst 33258)
Synonyms	Hoechst 33342; 23491-52-3; Bisbenzimide; hoechst33342; UNII-99KZS6CNZX; Ho 342; 2'-(4-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-1H,1'H-2,5'-bibenzo[d]imidazole; EINECS 245-691-1; 99KZS6CNZX; 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-benzimidazole; CHEMBL343002; CHEBI:51232; 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bi-1H-benzimidazole; 2'-(4'-Ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bis-1H-benzimidazole trihydrochloride trihydrate Click to Show/Hide
Indication	In total 1 Indication(s) Solid tumour/cancer [ICD-11: 2A00-2F9Z] Terminated [1]
Structure
Drug Resistance Disease(s)	Disease(s) with Clinically Reported Resistance for This Drug (1 diseases) Pneumonia [ICD-11: CA40] [1]
Target	Human Deoxyribonucleic acid (hDNA)	NOUNIPROTAC	[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula	C27H28N6O
IsoSMILES	CCOC1=CC=C(C=C1)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C
InChI	1S/C27H28N6O/c1-3-34-21-8-4-18(5-9-21)26-28-22-10-6-19(16-24(22)30-26)27-29-23-11-7-20(17-25(23)31-27)33-14-12-32(2)13-15-33/h4-11,16-17H,3,12-15H2,1-2H3,(H,28,30)(H,29,31)
InChIKey	PRDFBSVERLRRMY-UHFFFAOYSA-N
PubChem CID	1464
ChEBI ID	CHEBI:51232
TTD Drug ID	D0G2JZ
VARIDT ID	DR01292

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-12: Respiratory system diseases

Click to Show/Hide the Resistance Disease of This Class

Pneumonia [ICD-11: CA40]

Click to Show/Hide

Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: MATE family efflux transporter (ABEM)			[1]
Molecule Alteration	Expression	Inherence	Molecule Info
Resistant Disease	Acinetobacter baumannii infection [ICD-11: CA40.4]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Escherichia coli kAM32		562
Experiment for Drug Resistance	MIC assay
Mechanism Description	AbeM was found to be an H+-coupled multidrug efflux pump and a unique member of the MATE family which lead to drug resistance.

References

Ref 1	AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob Agents Chemother. 2005 Oct;49(10):4362-4. doi: 10.1128/AAC.49.10.4362-4364.2005.