Drug Information

Drug (ID: DG00368) and It's Reported Resistant Information

Name	4-Nitroquinoline N-oxide
Synonyms	4-Nitroquinoline N-oxide; 56-57-5; 4-Nitroquinoline 1-oxide; 4-Nitroquinoline-1-oxide; 4-NITROQUINOLINE-N-OXIDE; Nitrochin; 4-NQO; Quinoline, 4-nitro-, 1-oxide; 4-Nitroquinoline oxide; 4-nitro-1-oxidoquinolin-1-ium; 4 NQO; 4-nitroquinolin-1-ium-1-olate; CHEBI:16907; 4-Nitroquinolin-1-oxide; Quinoline, 4-nitro-, oxide; CCRIS 458; 4-nitroquinolin-1-ol; HSDB 4316; 4-Nitrochinolin N-oxid; NSC 19645; AI3-60200; UNII-X5081510EV; 4-Nitrochinoline-N-oxide; BIDD:ER0541; SCHEMBL105454; CHEMBL127655; WLN: T66 BNJ BO ENW; DTXSID5025780; CS-D0398; EX-A4093; NSC19645; ZINC1529664; 4-Nitroquinoline N-oxide, >=98%; AB4039; MFCD00006738; NSC-19645; AKOS015897246; SB67483; X5081510EV; AS-58188; DB-052942; FT-0619297; N0250; Z2900; 4-Nitroquinoline N-oxide, analytical standard; C03474; 95599-EP2277881A1; 95599-EP2305672A1; AC-907/25014229; Quinoline, 4-nitro-, 1-oxide (6CI,8CI,9CI); J-515890; J-640451; J-800475; Q4637188; NQO Click to Show/Hide
Structure
Drug Resistance Disease(s)	*Disease(s) with Resistance Information Validated by in-vivo* Model for This Drug** (1 diseases) Fungal infection [ICD-11: 1F29-1F2F] [1]
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Formula	C9H6N2O3
IsoSMILES	C1=CC=C2C(=C1)C(=CC=[N+]2[O-])[N+](=O)[O-]
InChI	1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H
InChIKey	YHQDZJICGQWFHK-UHFFFAOYSA-N
PubChem CID	5955

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

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Fungal infection [ICD-11: 1F29-1F2F]

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Protein SNQ2 (SNQ2)			[1]
Molecule Alteration	Expression	Up-regulation	Molecule Info
Resistant Disease	Fungal infection [ICD-11: 1F29-1F2F]		Disease Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Saccharomyces cerevisiae W303-1A		580240
Mechanism Description	The yeast gene SNQ2, which encodes a multidrug resistance ABC superfamily protein, is required for resistance to the mutagen 4-nitroquinoline N-oxide.

References

Ref 1	Functional analysis of the promoter of the yeast SNQ2 gene encoding a multidrug resistance transporter that confers the resistance to 4-nitroquinoline N-oxide. Biosci Biotechnol Biochem. 1999 Jan;63(1):162-7. doi: 10.1271/bbb.63.162.