Drug Information

Drug (ID: DG00245) and It's Reported Resistant Information

Name	Amorolfine
Synonyms	Loceryl; Pekiron; MT-861; Amorolfine (cream, onychomycosis); Ro-14-4767; Amorolfine (cream, onychomycosis), Roche; Ro-14-4767/002 Click to Show/Hide
Indication	In total 1 Indication(s) Nail/perionychium infection [ICD-11: EE12] Approved [1]
Structure
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Formula	C21H35NO
IsoSMILES	CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2C[C@H](O[C@H](C2)C)C
InChI	1S/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16 ,17-,18+
InChIKey	MQHLMHIZUIDKOO-AYHJJNSGSA-N
PubChem CID	54260
ChEBI ID	CHEBI:599440
TTD Drug ID	D0QC3M
DrugBank ID	DB09056

Type(s) of Resistant Mechanism of This Drug

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Their Corresponding Diseases

ICD-01: Infectious/parasitic diseases

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Candidosis [ICD-11: 1F23]

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)		Click to Show/Hide
Key Molecule: Pleiotropic ABC efflux transporter of multiple drugs CDR1 (CDR1)			[1]
Molecule Alteration	Deletion mutation	Deleteion	Molecule Info
Sensitive Disease	Recurrent oropharyngeal candidiasis [ICD-11: 1F23.6]		Disease Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Candida albicans strain DSY448		5476
Experiment for Molecule Alteration	PCR; Southern blotting analysis; Northern blottling analysis
Experiment for Drug Resistance	Growth differences between the different C. albicans strains assay
Mechanism Description	The delta cdr1 mutant was also hypersusceptible to other antifungal agents (terbinafine and amorolfine) and to different metabolic inhibitors (cycloheximide, brefeldin A, and fluphenazine).

References

Ref 1	Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother. 1996 Oct;40(10):2300-5. doi: 10.1128/AAC.40.10.2300.