Drug Information

Drug (ID: DG00217) and It's Reported Resistant Information
Name
Parthenolide
Synonyms
Parthenolide; 20554-84-1; (-)-Parthenolide; CHEBI:7939; Parthenolide, Tanacetum parthenium; 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone; partenolide; C15H20O3; 29552-41-8; Prestwick2_000550; Prestwick3_000550; Epitope ID:115014; SCHEMBL8220; BSPBio_001308; BSPBio_000599; MLS002153872; CHEMBL465158; BPBio1_000659; SCHEMBL13367522; BCBcMAP01_000041; Parthenolide, > MolPort-008-268-168; MolPort-003-959-089; HMS1361B10; HMS3402B10; HMS1989B10; HMS1791B10; HMS1569N21; HMS2096N21
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Structure
Target Inhibitor of nuclear factor kappa-B kinase beta (IKKB) IKKB_HUMAN [1]
Nuclear factor NF-kappa-B (NFKB) NFKB1_HUMAN ;
NFKB2_HUMAN ;
TF65_HUMAN ;
RELB_HUMAN ;
REL_HUMAN 		[1]
Click to Show/Hide the Molecular Information and External Link(s) of This Drug
Formula
C15H20O3
IsoSMILES
C/C/1=C\\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
InChI
1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1
InChIKey
KTEXNACQROZXEV-PVLRGYAZSA-N
PubChem CID
7251185
ChEBI ID
CHEBI:7939
TTD Drug ID
D0M4KE
DrugBank ID
DB13063
Type(s) of Resistant Mechanism of This Drug
  EADR: Epigenetic Alteration of DNA, RNA or Protein
  UAPP: Unusual Activation of Pro-survival Pathway
Drug Resistance Data Categorized by Their Corresponding Diseases
ICD-02: Benign/in-situ/malignant neoplasm
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Lung cancer [ICD-11: 2C25]
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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: hsa-miR-107 [1]
Molecule Alteration Expression
Up-regulation
 Molecule Info 
Sensitive Disease Non-small cell lung cancer [ICD-11: 2C25.Y]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell apoptosis Activation hsa04210
Cell invasion Inhibition hsa05200
Cell migration Inhibition hsa04670
Cell proliferation Inhibition hsa05200
Cell viability Inhibition hsa05200
In Vitro Model A549 cells Lung Homo sapiens (Human) CVCL_0023
Experiment for
Molecule Alteration		 RT-qPCR
Experiment for
Drug Resistance		 SRB assay; BrdU assay
Mechanism Description microRNA-107 targets IkBkG and sensitizes A549 cells to parthenolide.
       Unusual Activation of Pro-survival Pathway (UAPP) Click to Show/Hide
Key Molecule: NF-kappa-B essential modulator (IKBKG) [1]
Molecule Alteration Expression
Down-regulation
 Molecule Info 
Sensitive Disease Non-small cell lung cancer [ICD-11: 2C25.Y]
 Disease Info 
Experimental Note Revealed Based on the Cell Line Data
Cell Pathway Regulation Cell colony Inhibition hsa05200
Cell proliferation Inhibition hsa05200
Cell viability Inhibition hsa05200
In Vitro Model A549 cells Lung Homo sapiens (Human) CVCL_0023
Experiment for
Molecule Alteration		 Western blot analysis
Experiment for
Drug Resistance		 SRB assay; BrdU assay
Mechanism Description microRNA-107 targets IkBkG and sensitizes A549 cells to parthenolide.
References
Ref 1 MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide. Anticancer Res. 2018 Nov;38(11):6309-6316. doi: 10.21873/anticanres.12987.

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