Disease Information

General Information of the Disease (ID: DIS00412)
Name
Myocardial injury
ICD
ICD-11: NB31
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
Click to Show/Hide the Full List of Drugs
Catalpol
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: Nuclear paraspeckle assembly transcript 1 (NEAT1) [1]
Resistant Disease Myocardial injury [ICD-11: NB31.Z]
Molecule Alteration Up-regulation
Interaction
 Molecule Info 
Resistant Drug Catalpol
 Drug Info 
Experimental Note Revealed Based on the Cell Line Data
In Vitro Model Mouse harvested primary cardiomyocytes N.A. Mus musculus (Mouse) N.A.
Experiment for
Molecule Alteration		 Luciferase assay; ChIP assay
Experiment for
Drug Resistance		 TUNEL assay; Cellular ROS detection assay
Mechanism Description Inhibition of LncRNA Neat1 by catalpol via suppressing transcriptional activity of NF-kappa-B attenuates cardiomyocyte apoptosis.
References
Ref 1 Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axisBiochimie. 2019 Oct;165:90-99. doi: 10.1016/j.biochi.2019.05.005. Epub 2019 May 9.

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