Disease Information

General Information of the Disease (ID: DIS00404)

• Name: Irritable bowel syndrome
• ICD: ICD-11: DD91

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s) 1 drug(s) in total

Picric acid

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Taurine up-regulated 1 (TUG1) [1]

• Resistant Disease: Irritable bowel syndrome [ICD-11: DD91.0]
• Molecule Alteration: Down-regulation; Interaction
• Resistant Drug: Picric acid
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: ICCs; Breast; Homo sapiens (Human); CVCL_B5N7
• Experiment for Molecule Alteration: qRT-PCR; Western bloting analysis; Overexpression assay
• Experiment for Drug Resistance: CCK8 assay; Flow cytometry assay
• Mechanism Description: TUG1 attenuated TNF-alpha-caused apoptosis and inflammatory response in ICC by down-regulating miR-127 and then inactivating NF-kappa-B and Notch pathways.

References

• Ref 1: Long non-coding RNA TUG1 enhances chemosensitivity in non-small cell lung cancer by impairing microRNA-221-dependent PTEN inhibitionAging (Albany NY). 2019 Sep 18;11(18):7553-7569. doi: 10.18632/aging.102271. Epub 2019 Sep 18.