Disease Information

General Information of the Disease (ID: DIS00400)

Type(s) of Resistant Mechanism of This Disease

EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Investigative Drug(s)

2 drug(s) in total

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Catalpol

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Nuclear paraspeckle assembly transcript 1 (NEAT1)				[1]
Resistant Disease	Diabetic cardiomyopathy [ICD-11: BC43.7]
Molecule Alteration	Down-regulation		Interaction	Molecule Info
Resistant Drug	Catalpol			Drug Info
Experimental Note	Discovered Using In-vivo Testing Model
In Vitro Model	Mouse cardiomyocytes	Heart	Mus musculus (Mouse)	CVCL_JK52
In Vivo Model	Diabetes male C57BL/6 mice model			Mus musculus
Experiment for Molecule Alteration	Luciferase assay; Overexpression assay; Knockdown assay
Experiment for Drug Resistance	TUNEL assay
Mechanism Description	Catalpol alleviated myocardial damage by regulating Neat1/miR-140-5p/HDAC4 axis in DCM mice.

D-Glucose

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Drug Resistance Data Categorized by Their Corresponding Mechanisms
Epigenetic Alteration of DNA, RNA or Protein (EADR)			Click to Show/Hide
Key Molecule: Long non-protein coding RNA (NONRATT007560.2)				[2]
Resistant Disease	Diabetic cardiomyopathy [ICD-11: BC43.7]
Molecule Alteration	Up-regulation		Expression	Molecule Info
Resistant Drug	D-Glucose			Drug Info
Experimental Note	Identified from the Human Clinical Data
In Vitro Model	Rat primary cardiomyocytes	Embryonic heart	Rattus norvegicus (Rat)	CVCL_0286
Experiment for Molecule Alteration	RNA-seq assay
Experiment for Drug Resistance	Cellular ROS detection assay; Flow cytometry assay
Mechanism Description	RNA-Seq analysis and functional characterization revealed LncRNA NONRATT007560.2 regulated cardiomyocytes oxidative stress and apoptosis induced by high glucose.

References

Ref 1	Catalpol attenuates cardiomyocyte apoptosis in diabetic cardiomyopathy via Neat1/miR-140-5p/HDAC4 axisBiochimie. 2019 Oct;165:90-99. doi: 10.1016/j.biochi.2019.05.005. Epub 2019 May 9.
Ref 2	RNA-Seq analysis and functional characterization revealed lncRNA NONRATT007560.2 regulated cardiomyocytes oxidative stress and apoptosis induced by high glucoseJ Cell Biochem. 2019 Oct;120(10):18278-18287. doi: 10.1002/jcb.29134. Epub 2019 May 29.