Disease Information

General Information of the Disease (ID: DIS00395)

• Name: Neurodegeneration
• ICD: ICD-11: 8A07

Type(s) of Resistant Mechanism of This Disease

  EADR: Epigenetic Alteration of DNA, RNA or Protein

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Morphine

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Epigenetic Alteration of DNA, RNA or Protein (EADR)

Key Molecule: Mitochondrially encoded cytochrome c oxidase II (MT-CO2) [1]

• Resistant Disease: Morphine mediated neurodegeneration [ICD-11: 8A07.0]
• Molecule Alteration: Up-regulation; Expression
• Resistant Drug: Morphine
• Experimental Note: Revealed Based on the Cell Line Data
• In Vitro Model: A172 cells; Brain; Homo sapiens (Human); CVCL_0131
• In Vitro Model: Human primary astrocytes; N.A.; Homo sapiens (Human); N.A.
• In Vitro Model: BV-2 microglial cells; Brain; Mus musculus (Mouse); CVCL_0182
• In Vivo Model: C57BL/6N WT mice model; Tlr7-/- mice model; Pregnant WT mice model; Mus musculus
• Experiment for Molecule Alteration: Knockdown assay
• Experiment for Drug Resistance: Phagocytosis assay; Flow cytometry assay
• Mechanism Description: Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration.

References

• Ref 1: Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated NeurodegenerationMol Ther Nucleic Acids. 2018 Dec 7;13:450-463. doi: 10.1016/j.omtn.2018.09.019. Epub 2018 Sep 29.