Disease Information

General Information of the Disease (ID: DIS00273)
Name
Trigeminal neuralgia
ICD
ICD-11: 8B82
Resistance Map
Type(s) of Resistant Mechanism of This Disease
  EADR: Epigenetic Alteration of DNA, RNA or Protein
Drug Resistance Data Categorized by Drug
Investigative Drug(s)
1 drug(s) in total
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Picric acid
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Drug Resistance Data Categorized by Their Corresponding Mechanisms
       Epigenetic Alteration of DNA, RNA or Protein (EADR) Click to Show/Hide
Key Molecule: Predicted gene 14461 (Gm14461) [1]
Resistant Disease Trigeminal neuralgia [ICD-11: 8B82.0]
Molecule Alteration Up-regulation
Expression
 Molecule Info 
Resistant Drug Picric acid
 Drug Info 
Experimental Note Discovered Using In-vivo Testing Model
In Vivo Model C57BL/6 J mouse model Mus musculus
Experiment for
Molecule Alteration		 qRT-PCR; Western bloting analysis; Knockdown assay; Overexpression assay; Mimic
Mechanism Description Gm14461 promoted pain transmission (reduced MWT value) in a CCI-ION-induced mouse TN model.
References
Ref 1 Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgiaJ Inflamm (Lond). 2020 Jan 3;17:1. doi: 10.1186/s12950-019-0231-1. eCollection 2020.

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