Disease Information

General Information of the Disease (ID: DIS00249)

• Name: Lactic acidosis
• ICD: ICD-11: 5C73

Type(s) of Resistant Mechanism of This Disease

  UAPP: Unusual Activation of Pro-survival Pathway

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Erlotinib

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Unusual Activation of Pro-survival Pathway (UAPP)

Key Molecule: Protein kinase C (PRKC) [1]

• Resistant Disease: Lactic acidosis [ICD-11: 5C73.Z]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Erlotinib
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell migration; Activation; hsa04670
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• In Vitro Model: HCC827 cells; Lung; Homo sapiens (Human); CVCL_2063
• Experiment for Molecule Alteration: Western blotting analysis
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: The resistance might occur by several mechanisms, including epigenetic regulation, drug target alteration, multidrug resistance, cancer cell metabolic alteration, or TME factors.

Key Molecule: Protein kinase C (PRKC) [1]

• Resistant Disease: Lactic acidosis [ICD-11: 5C73.Z]
• Molecule Alteration: Expression; Up-regulation
• Resistant Drug: Erlotinib
• Experimental Note: Identified from the Human Clinical Data
• Cell Pathway Regulation: Cell migration; Activation; hsa04670
• In Vitro Model: A549 cells; Lung; Homo sapiens (Human); CVCL_0023
• In Vitro Model: HCC827 cells; Lung; Homo sapiens (Human); CVCL_2063
• Experiment for Molecule Alteration: Western blotting analysis
• Experiment for Drug Resistance: MTT assay
• Mechanism Description: The resistance might occur by several mechanisms, including epigenetic regulation, drug target alteration, multidrug resistance, cancer cell metabolic alteration, or TME factors.

References

• Ref 1: l-lactic acidosis confers insensitivity to PKC inhibitors by competing for uptake via monocarboxylate transporters .J Cell Physiol. 2022 Jan;237(1):934-948. doi: 10.1002/jcp.30570. Epub 2021 Sep 1. 10.1002/jcp.30570