Disease Information

General Information of the Disease (ID: DIS00141)

• Name: Shock
• ICD: ICD-11: MG40

Type(s) of Resistant Mechanism of This Disease

  IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Dexamethasone

Drug Sensitivity Data Categorized by Their Corresponding Mechanisms

Irregularity in Drug Uptake and Drug Efflux (IDUE)

Key Molecule: ATP-binding cassette sub-family B5 (ABCB5) [1]

• Sensitive Disease: Shock [ICD-11: MG40.0]
• Molecule Alteration: Expression; Down-regulation
• Sensitive Drug: Dexamethasone
• Experimental Note: Revealed Based on the Cell Line Data
• In Vivo Model: Adult male CF-1 abcb1a(+/+) mice moodel; Crl:CF1- abcb1a(-/-) mice model; Mus musculus
• Mechanism Description: The multidrug resistance transporter, P-glycoprotein (P-gp), contributes to highly lipophilic molecules penetrating the brain from the blood at a much lower rate than expected, and has numerous substrates, inhibitors and modulators. Dexamethasone was shown to be transported in vitro by abcb1b and showed little to no transport by abcb1a; however, in vivo tissue accumulation of dexamethasone was increased in abcb1a-deficient mice compared to abcb1a-deficien.

References

• Ref 1: Changes in the brain accumulation of glucocorticoids in abcb1a-deficient CF-1 mice. J Neuroendocrinol. 2012 Nov;24(11):1440-6. doi: 10.1111/j.1365-2826.2012.02353.x.