Disease Information

General Information of the Disease (ID: DIS00113)

Name	Psychosis
ICD	ICD-11: 6D8Z

Type(s) of Resistant Mechanism of This Disease

IDUE: Irregularity in Drug Uptake and Drug Efflux

Drug Resistance Data Categorized by Drug

Approved Drug(s)

3 drug(s) in total

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Chlorpromazine

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[1]
Sensitive Disease	Psychosis [ICD-11: 6D8Z.0]
Molecule Alteration	Expression		Down-regulation	Molecule Info
Sensitive Drug	Chlorpromazine			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	L-MDR1 cells(Sus scrofa (Pig))	Kidney	Homo sapiens (Human)	CVCL_0391
	LLC-Pk1 cells(Sus scrofa (Pig))	Kidney	Homo sapiens (Human)	CVCL_0391
Experiment for Drug Resistance	Flow cytometric assay
Mechanism Description	The multidrug resistance transporter, P-glycoprotein (P-gp), is involved in efflux transport of several antipsychotics in the blood-brain barrier (BBB). All the antipsychotics showed various degrees of inhibitory effects on P-gp activity at concentrations ranging from 1 to 100 uM. However, risperidone and olanzapine are the most likely agents that may inhibit P-gp activity.

Clozapine

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[1]
Sensitive Disease	Psychosis [ICD-11: 6D8Z.0]
Molecule Alteration	Expression		Down-regulation	Molecule Info
Sensitive Drug	Clozapine			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	L-MDR1 cells(Sus scrofa (Pig))	Kidney	Homo sapiens (Human)	CVCL_0391
	LLC-Pk1 cells(Sus scrofa (Pig))	Kidney	Homo sapiens (Human)	CVCL_0391
Experiment for Drug Resistance	Flow cytometric assay
Mechanism Description	The multidrug resistance transporter, P-glycoprotein (P-gp), is involved in efflux transport of several antipsychotics in the blood-brain barrier (BBB). All the antipsychotics showed various degrees of inhibitory effects on P-gp activity at concentrations ranging from 1 to 100 uM. However, risperidone and olanzapine are the most likely agents that may inhibit P-gp activity.

Haloperidol

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Drug Sensitivity Data Categorized by Their Corresponding Mechanisms
Irregularity in Drug Uptake and Drug Efflux (IDUE)			Click to Show/Hide
Key Molecule: Multidrug resistance protein 1 (ABCB1)				[1]
Sensitive Disease	Psychosis [ICD-11: 6D8Z.0]
Molecule Alteration	Expression		Down-regulation	Molecule Info
Sensitive Drug	Haloperidol			Drug Info
Experimental Note	Revealed Based on the Cell Line Data
In Vitro Model	L-MDR1 cells(Sus scrofa (Pig))	Kidney	Homo sapiens (Human)	CVCL_0391
	LLC-Pk1 cells(Sus scrofa (Pig))	Kidney	Homo sapiens (Human)	CVCL_0391
Experiment for Drug Resistance	Flow cytometric assay
Mechanism Description	The multidrug resistance transporter, P-glycoprotein (P-gp), is involved in efflux transport of several antipsychotics in the blood-brain barrier (BBB). All the antipsychotics showed various degrees of inhibitory effects on P-gp activity at concentrations ranging from 1 to 100 uM. However, risperidone and olanzapine are the most likely agents that may inhibit P-gp activity.

References

Ref 1	Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.