Disease Information

General Information of the Disease (ID: DIS00040)

• Name: Cryptococcosis
• ICD: ICD-11: 1F27

Type(s) of Resistant Mechanism of This Disease

  ADTT: Aberration of the Drug's Therapeutic Target

Drug Resistance Data Categorized by Drug

Approved Drug(s) 1 drug(s) in total

Fluconazole

Drug Resistance Data Categorized by Their Corresponding Mechanisms

Aberration of the Drug's Therapeutic Target (ADTT)

Key Molecule: Lanosterol 14-alpha demethylase (ERG11) [1]

• Resistant Disease: Recurrent cryptococcosis [ICD-11: 1F27.0]
• Molecule Alteration: Missense mutation; p.G484S (c.G1855T)
• Resistant Drug: Fluconazole
• Experimental Note: Identified from the Human Clinical Data
• In Vitro Model: Cryptococcus neoformans stiain CN-5; 5207
• Experiment for Molecule Alteration: Genomic sequence assay
• Experiment for Drug Resistance: Microdilution and E-test methods assay
• Mechanism Description: A point mutation (G1855T) in the ERG11 gene was detected in the FCZ-resistant isolate (CN-5) only. And this mutation is responsible for the amino acid substitution glycine 484 for serine (G484S) in the ERG11 deduced protein sequence of C. neoformans.

References

• Ref 1: G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate. Antimicrob Agents Chemother. 2003 Nov;47(11):3653-6. doi: 10.1128/AAC.47.11.3653-3656.2003.